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代喜平,冯 梅,卢爱丽,高红霞,庄壮锋.间充质干细胞移植治疗脊髓损伤患者的疗效分析[J].中国康复医学杂志,2012,27(6):538~541
间充质干细胞移植治疗脊髓损伤患者的疗效分析    点此下载全文
代喜平  冯 梅  卢爱丽  高红霞  庄壮锋
广东省中医院大学城医院,510002
基金项目:
DOI:
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摘要:
      摘要 目的:探讨间充质干细胞(MSCs)移植治疗脊髓损伤的临床疗效。 方法:对23例脊髓损伤患者在腰椎穿刺方式下分别行骨髓MSCs或脐血MSCs移植术,术前和术后均进行安全性指标评价,干细胞移植前和移植3个月后分别进行美国脊髓损伤学会损伤分级评分。 结果:所有患者干细胞治疗前后安全性指标评价差异无显著性意义(P>0.05),未出现严重的不良反应,同时不完全脊髓损伤患者行干细胞移植3个月后在运动功能、轻触觉及针刺觉方面均有明显改善(P<0.05),而完全性脊髓损伤患者则在轻触觉及针刺觉方面有改善(P<0.05),运动功能未见明显进步(P>0.05),同时骨髓MSCs移植的患者3个月后运动功能的改善优于脐血MSCs移植的患者。 结论:MSCs移植治疗可以改善脊髓损伤患者的感觉功能,但不完全脊髓损伤患者运动功能的恢复优于完全性脊髓损伤患者,同时骨髓MSCs移植的患者运动功能的改善优于脐血MSCs移植的患者。
关键词:脊髓损伤  间充质干细胞  移植
Treatment effect of mesenchymal stem cell transplantation on spinal cord injury: 23-case curative effect analysis    Download Fulltext
University City Branch of Guangdong Provincial Hospital of Traditional Chinese Medicine, 510002
Fund Project:
Abstract:
      Abstract Objective: To investigate the effect of mesenchymal stem cells (MSCs) transplantation on spinal cord injury (SCI). Method: Twenty-three SCI patients were enrolled into the bone marrow MSCs or umbilical cord blood-derived MSCs transplantation via lumbar puncture. Preoperative and postoperative safety index were evaluated. The severity of SCI was assessed with ASIA scale before transplantation and 3 months after that. Result: Statistical results showed that safety index of all patients before and after the treatment had no significant difference(P>0.05) and there was no serious side effect happened. At the same time, improvement of motor function, tactile sense and sensation of pinprick were observed obviously (P<0.05) in patients with incomplete SCI 3 months after the transplantation. However, in complete SCI group, tactile sense and sensation of pinprick improved(P<0.05) with barely advance in motor function (P>0.05). Three months after transplantation motor function improved markedly in bone marrow MSCs group compared with the umbilical cord blood-derived MSCs group. Conclusion: MSCs transplantation could promote sensory function and motor function recovery that was better in incomplete SCI patients than the complete SCI ones. Bone marrow MSCs transplantation was more effective for improving motor function than umbilical cord blood-derived MSCs.
Keywords:spinal cord injury  mesenchymal stem cells transplantation
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