| 朱燕平,寇雪莲,何松彬,唐维国.高压氧联合复方海蛇胶囊对血管性痴呆大鼠学习记忆能力行为学的影响[J].中国康复医学杂志,2013,28(1):18~22 |
| 高压氧联合复方海蛇胶囊对血管性痴呆大鼠学习记忆能力行为学的影响 点此下载全文 |
| 朱燕平 寇雪莲 何松彬 唐维国 |
| 温州医学院附属舟山医院神经内科，浙江舟山，316000 |
| 基金项目：浙江省中医药局课题资助项目（2008CA112） |
| DOI： |
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| 摘要
目的：研究高压氧联合复方海蛇胶囊对血管性痴呆大鼠学习记忆能力行为学的影响。
方法：成年Sprague-Dawly雄性大鼠40只, 体重250—300g，采用线栓法再灌注大脑中动脉梗死建立血管性痴呆大鼠模型，随机分为假手术组、梗死模型组、高压氧组、药物组、高压氧＋药物组，每组8只，用高压氧或（和）复方海蛇胶囊干预各模型组4周后，行Morris水迷宫检测大鼠学习记忆能力。
结果：①水迷宫平均逃避潜伏期比较，高压氧组（41.15±6.75s）、药物组(44.11±6.05s)和高压氧+药物组(29.32±3.72s)均明显短于梗死模型组(67.05±9.00s)(P<0.05); 高压氧+药物组均明显短于高压氧组、药物组(P<0.05); 高压氧组与药物组相比较,其差异无显著性意义(P>0.05)。②平均游泳路程比较，高压氧组(7631.89±1277.73mm)、药物组(8114.48±1091.82mm)和高压氧+药物组(5699.27±1339.82mm)均明显短于梗死模型组(12492.46±2161.74mm)(P<0.05); 高压氧+药物组均明显短于高压氧组、药物组(P<0.05); 高压氧组与药物组相比较,其差异无显著性意义(P>0.05)。③跨越原平台位置的次数比较，高压氧组(2.74±0.65次)、药物组(2.25±0.87次)、高压氧+药物组(3.82±0.96次)跨越平台次数较梗死模型组(1.06±0.55次)明显增加（P<0.05）；高压氧+药物组明显多于高压氧组、药物组(P<0.05); 高压氧组与药物组相比较,其差异无显著性意义(P>0.05)。④平台滞留时间的比较，高压氧组（30.05±3.58s）、药物组（30.24±5.13s）、高压氧+药物组（35.29±3.51s）平台滞留时间较梗死模型组（24.52±4.05s）明显增加（P<0.05）； 高压氧+药物组明显长于高压氧组、药物组(P<0.05); 高压氧组与药物组相比较,其差异无显著性意义。
结论：高压氧或复方海蛇胶囊治疗均可改善血管性痴呆大鼠的学习记忆能力，如果二者联合使用治疗，大鼠学习记忆能力改善更为显著。 |
| 关键词：复方海蛇胶囊 高压氧 血管性痴呆 学习记忆 |
| Effects of hyperbaric oxygen combined with reinhartdt and sea cumber capsule therapy on abilities of learning and memory in vascular dementia rats Download Fulltext |
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| Department of Neurology，Zhoushan Hospital Zhejiang Province, 316000 |
| Fund Project: |
| Abstract: |
| Abstract
Objective:To investigate the effect's of hyperbaric oxygen(HBO) combined with reinhartdt and sea cumber capsule(RSC) therapy on abilities of learning and memory in vascular dementia rats.
Method: In forty Sprague-Dawly rats weighted 250—300g, the reperfusion middle cerebral artery occlusion (rMCAO) models were established with thread embolism method. These model rats were divided into five groups: sham-operated(SHAM) group, MCAO mode(MCAO), HBO treatment(HBO) group, reinhartdt and sea cumber capsule treatment(RSC) group and HBO combined with RSC treatment(HBO+RSC) group, 8 rats in each group. At the end of 4 week treatment with HBO and/or RSC, the abilities of learning and memory of rats were assessed with Morris water maze.
Result: ①In Morris water maze test, the average escape latencies in HBO group（41.15±6.75s）,RSC group(44.11±6.05s) and HBO+RSC group(29.32±3.72s) were significantly shorter than that in MCAO group(67.05±9.00s) (P<0.05); the average escape latency in HBO+RSC group was significantly shorter than that in HBO group or RSC group(P<0.05); no significant difference was found between RSC group and HBO group(P>0.05).②The average swimming path lengths in HBO group(7631.89±1277.73mm),RSC group(8114.48±1091.82mm)and HBO+RSC group(5699.27±1339.82mm) were significantly shorter than that in MCAO group(12492.46±2161.74mm) (P<0.05); the average swimming path length in HBO+RSC group was significantly shorter than that in HBO group or RSC group (P<0.05); no significant difference was found between RSC group and HBO group (P>0.05). ③The striding platform times in HBO group(2.74±0.65 times),RSC group(2.25±0.87 times) and HBO+ RSC(3.82±0.96 times) were significantly longer than that in MCAO group(1.06±0.55 times) (P<0.05); the striding platform times in HBO+RSC group was significantly more than that in HBO group or RSC group (P<0.05); no significant difference was found between RSC group and HBO group(P>0.05).④The platform detention time in HBO group（30.05±3.58s）,RSC group（30.24±5.13s） and HBO+RSC group（35.29±3.51s） increased significantly than that in MCAO group（24.52±4.05s）(P<0.05); the platform detention time in HBO+RSC group increased significantly than that in HBO group or RSC group(P<0.05); no significant difference was found between RSC group and HBO group.
Conclusion: HBO and/or RSC therapy could improve learning and memory abilities in vascular dementia rats effectively. The effect of HBO combined with RSC therapy in vascular dementia rats was much better than either of them alone. |
| Keywords:reinhartdt and sea cumber capsule hyperbaric oxygen vascular dementia learning-memory |
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