| 崔成埈,郭长青,付伟涛,梁楚西,黄怡然,孙红梅,许 红,郭 健,赵淑英,张丽萍,朴起范.针刀用于腰椎间盘突出症根性神经痛大鼠中枢镇痛的机制研究[J].中国康复医学杂志,2015,(4):324~328 |
| 针刀用于腰椎间盘突出症根性神经痛大鼠中枢镇痛的机制研究 点此下载全文 |
| 崔成埈 郭长青 付伟涛 梁楚西 黄怡然 孙红梅 许 红 郭 健 赵淑英 张丽萍 朴起范 |
| 北京中医药大学针灸推拿学院，北京，100029 |
| 基金项目：北京中医药大学自主课题项目（53210100604209） |
| DOI： |
| 摘要点击次数: 1879 |
| 全文下载次数: 2029 |
| 摘要： |
| 摘要
目的：观察针刀疗法对腰椎间盘突出症根性神经痛大鼠下丘脑和脊髓中5-羟色胺、β-内啡肽含量的影响，探讨针刀疗法对腰椎间盘突出症根性神经痛干预作用的可能机制。
方法：将40只雄性SD大鼠随机分为正常组、假模型组、模型组、针刀组，共4组，每组10只。用热痛测试仪检测各组大鼠造模前后的缩爪潜伏期；HE染色观察L5神经根的病理学变化；造模后第8天分别取各组大鼠下丘脑和脊髓，采用双抗夹心ELISA方法检测下丘脑和脊髓中5-羟色胺、β-内啡肽的含量。
结果：模型组下丘脑和脊髓中5-羟色胺含量较正常组显著降低，差异有显著性意义（P＜0.05），针刀组较模型组显著升高，差异有显著性意义（P＜0.05）；模型组β-内啡肽含量较正常组显著升高，差异有显著性意义（P＜0.01），针刀组较模型组显著降低，差异有显著性意义（P＜0.05）。
结论：针刀治疗可调节中枢疼痛相关递质5-羟色胺和β-内啡肽的合成和分泌，降低中枢痛觉传递和痛觉过敏，从而有效地发挥了镇痛作用。 |
| 关键词：针刀疗法 腰椎间盘突出症 根性神经痛 5-羟色胺 β-内啡肽 |
| Effects of acupotomy on central analgesic mechanism of radicular pain of lumbar disc herniation in rats Download Fulltext |
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| College of Acupuncture and Moxibustion, Beijing University of Traditional Chinese Medicine, Beijing, 100029 |
| Fund Project: |
| Abstract: |
| Abstract
Objective: To observe effects of acupotomy on 5-hydroxytryptamine(5-HT) and β-endorphin（β-EP） in hypothalamus and spinal cord of rats with discogenic radiculalgia, so as to explore possible mechanism of acupotomy.
Method: Forty male SD rats were randomly divided into four groups: normal group, sham model group, model group and acupotomy group, 10 rats in each group. Samples were taken on the 8th d after modeling. The hypothalamus and spinal cord were taken to observe the changes of 5-HT and β-EP by ELISA.
Result: In model group, 5-HT in hypothalamus and spinal cord decreased significantly (P＜0.05) compared with normal group, in acupotomy group those increased compared with model group (P＜0.05); In model group, β-EP in hypothalamus and spinal cord increased significantly (P＜0.05) compared with normal group, in acupotomy group those decreased compared with model group (P＜0.05).
Conclusion: Acupotomy had benign effects on regulating 5-HT and β-EP in hypothalamus and spinal cord of rats with lumbar disc herniation and reducing central algotransmission and hyperalgia, so as to provide analgesic effect. |
| Keywords:acupotomy lumbar disc herniation radicular pain 5-hydroxytryptamine β-endorphin |
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