| 杨燕兴,李灵玲,刘鹏民,王 良,周达岸.电针联合游泳训练对脊髓全横断大鼠脊髓神经营养因子-3及血清谷丙转氨酶、谷草转氨酶的影响[J].中国康复医学杂志,2016,(6):641~646 |
| 电针联合游泳训练对脊髓全横断大鼠脊髓神经营养因子-3及血清谷丙转氨酶、谷草转氨酶的影响 点此下载全文 |
| 杨燕兴 李灵玲 刘鹏民 王 良 周达岸 |
| 辽宁医学院附属第三医院，锦州，121000 |
| 基金项目：辽宁医学院校长基金——奥鸿博泽研究生科研创新基金（AH2014016） |
| DOI： |
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| 摘要
目的：探讨电针联合游泳训练对脊髓全横断大鼠脊髓神经营养因子-3（NT-3）及血清谷丙转氨酶（ALT）、谷草转氨酶（AST）的影响。
方法：雌性成年SD大鼠180只，随机分为6个组（正常组，假手术组，损伤组，游泳组，电针组，联合组），每组30只。制作脊髓T10全横断损伤模型。术后第5天开始电针及游泳训练（电针每天30min，电流1mA，频率为2/100Hz，波型为疏密波。游泳第1周游一组，以后每周加一组，一组时间为4min。每周治疗7次）。对照组不进行治疗。术后7d、14d、21d、28d、35d进行运动功能评估（BBB评分），治疗结束时取材。用免疫组化及生化来检测相关因子的表达。
结果：①各治疗组的运动功能评分较损伤组均有提高（除第1周（P＞0.05）），并随时间的延长效果更为明显；在各干预组中，联合组运动功能的恢复最为突出（P＜0.01）。②治疗组大鼠脊髓损伤区NT-3表达较损伤组均有提高（P＜0.05），并随时间的延长而提高，治疗组之间联合组NT-3的表达更为突出（P＜0.01）。③各治疗组中血清ALT、AST的表达水平较损伤组均有下降（P＜0.05），联合组下降最为明显（P＜0.01）。
结论：游泳训练及电针能够促进脊髓损伤后运动功能的恢复，将两者联合应用效果更为明显。 |
| 关键词：督脉电针 游泳训练 脊髓全横断 神经营养因子-3 丙转氨酶 谷草转氨酶 |
| The effect of combining electroacupuncture and swimming training on NT-3, ALT and AST of rat after spinal cord transection Download Fulltext |
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| The Third Affiliated Hospital of Liaoning Medical College, Jinzhou, |
| Fund Project: |
| Abstract: |
| Abstract
Objective: To study the effect of combining electroacupuncture and swimming training on NT-3 and ALT and AST of rat after spinal cord transection
Method: 180 adult female SD rats were randomly divided into the normal group(30), sham-operated group (30), injured group(30), swimming group(30), electroacupuncture group(30), and combination group (30). T10 spinal cord transection performed on last 4 groups. Post operation day 5 began the electric acupuncture courtes periodes current， 30 minutes per day) and swimming training(the first week only 4 minutes a session, 7 times a week，one session more per week later until 5 sessions per day) for the last 3 groups. The other 2 groups accepted no treatment.
Result: ①The movement function of treated groups was better than untreated injured group(P＞0.05), the longer the treatment the better the improvement. The movement function index of the combination group increased more than electroacupuncture or swimming training separately . (P＜0.01). ② The expression of NT-3 of the treated groups increased more than the injured group (P＞0.05), and the combination group was better than the other two treated groups (P＜0.01). ③ Compared with the injured group, the expression of serum ALT and AST levels decreased in treated groups (P＞0.05), and the combination group fell the most among the 3 treated groups (P＜0.01).
Conclusion: Swimming training and electroacupuncture can promote the recovery of movement function after spinal cord transection, and the effect is more apparent if combine the two. |
| Keywords:governor vessel electro-acupuncture swimming training spinal cord transection neurotrophin-3 glutamic pyruvic transaminase glutamic oxaloacetic transaminase |
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